They'll send your ISP a DMCA claim. Even if you're your own ISP, unless you're a tier 1 they can DMCA your transit provider. Now that CloudFront has transparent pricing there's no reason not to use CDN if you can afford it.
No, the DMCA/OCILLA's safe harbor for transit providers doesn't require them to honor something like a takedown notice to be eligible. Only ISPs who store material at the direction of their users, on systems controlled by the ISP, and who want to take advantage of that safe harbor, have to honor takedown notices.
