I've run it against my nightscout data a few times to get insights to my profile. So yes, you should install it somewhere and run a CGM app such as xdrip which can transfer your libre2 data to your nightscout database.
So yes, if you are interested on autotune, a nightscout is required for now.
I use a cgm (libre2).
Can I use autotune to tune my carb ratio, basals etc. without looping? How was your experience in this?
Do I have to use nightscout to run autotune?