CIDER is a SLIME-like environment for Clojure and ClojureScript, with a client for Emacs, among many other editors. If there's not an equivalent for Python, I hope someone is working on it :-)
CIDER has been the best programming environment I have experienced (probably haven't tried enough of SLIME though). It combines coding with dynamic experimentation in such a fun way.
For literate programming, the Clojure/Clojurescript ecosystem keeps bringing up fascinating environments (in addition to CIDER+Org-mode and Clojupyter).
The pain point with CIDER for me has been, the complexity of setting it up and keeping it current (so many components to it Clojure, leiningen, cider, nrepl, etc), and the fact that it can't drop to a live REPL at the point of exception.
https://github.com/clojure-emacs/cider