I happen to have a gene mutation that makes methylation of B12 inefficient. I never did well in chemistry or biology for that matter, but my limited understanding is that methylation is necessary for it to be useful.
It turns out that you can buy methylated B12 called methylcobalamin. The more common form is cyanocobalamin, and is not very useful for people like myself.
That is my understanding, if anyone here knows better or more, please correct me.
Thanks for this added information. I discovered the same thing, with another family member where Methylcobalamin worked wonders and Cyanocobalamin didn't.
One thing I would add is that Methylcobalamin needs to be injected to work best. If people do not have your gene mutation, they are better off taking Cyanocobalamin.
PS: Whenever someone in family has major health issue which no one can get handle on - they reach out to me. My lifelong dream has been to cure Cancer using AI. Just started working on that.
Typically it is further up the methylation pathway. You might need methyltetrahydrofolate (5-MTHR, brand names Metafolin and Deplin) supplementation combined with methyl-B12.
It turns out that you can buy methylated B12 called methylcobalamin. The more common form is cyanocobalamin, and is not very useful for people like myself.
That is my understanding, if anyone here knows better or more, please correct me.